• Product NameTRAM-34
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.
• Target NameIκB/IKK inhibitor
• CAS No. 289905-88-0
• Calculated MW 344.84
• Formulation C22H17ClN2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4
  Pathways:NF-κb
  Receptor:IKCa1 (KCa3.1)
  Boling pt:
  Melting pt:
  Solubility:DMSO:0.4 mg/mL (1.15 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wulff H, et al. Proc Natl Acad Sci U S A, 2000, 97(14), 8151-8156.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting