• Product NamePD0325901
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPD0325901 (PD325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.
• Target NameMEK inhibitor
• CAS No. 391210-10-9
• Calculated MW 482.19
• Formulation C16H14F3IN2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[C@@H](CO)O
  Pathways:MAPK
  Receptor:MEK
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 40 mg/mL (82.95 mM); DMSO: 96 mg/mL (199.09 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Barrett SD, et al. Bioorg Med Chem Lett, 2008, 18(24), 6501-6504.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting