• Product NamePP1
• Brief DescriptionInhibitors
• Purification99.82%
• Biological ActivityPP1 is a potent and selective Src inhibitor for Lck/Fyn with IC50 of 5 nM/ 6 nM.
• Target NameBcr-Abl inhibitor; c-Kit inhibitor; EGFR inhibitor; Src inhibitor
• CAS No. 172889-26-8
• Calculated MW 281.36
• Formulation C16H19N5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC=C(C=C1)C1=NN(C2=NC=NC(N)=C12)C(C)(C)C |c:3,5,13,t:1,8,11,16|
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling; JAK/STAT signaling
  Receptor:Bcr-Abl; Kit; EGFR; Fyn; Lck
  Boling pt:
  Melting pt:
  Solubility:DMSO:4 mg/mL (14.21 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hanke JH, et al. J Biol Chem, 1996, 271(2), 695-701.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting