• Product NameDolutegravir (GSK1349572)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityDolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
• Target NameHIV Protease inhibitor
• CAS No. 1051375-16-6
• Calculated MW 419.38
• Formulation C20H19F2N3O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:[H][C@]12CN3C=C(C(=O)NCC4=C(F)C=C(F)C=C4)C(=O)C(O)=C3C(=O)N1[C@H](C)CCO2 |r,c:10,16,22,t:4,13|
  Pathways:Microbiology&virology; Proteases/Proteasome
  Receptor:HIV integrase
  Boling pt:
  Melting pt:
  Solubility:DMSO:83 mg/mL warmed (197.91 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Charpentier C, et al. AIDS. 2010, 24(17), 2753-275

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting