• Product NameLEE011
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLEE011 is an orally available, and highly specific CDK4/6 inhibitor. Phase 3.
• Target NameCDK inhibitor
• CAS No. 1211441-98-3
• Calculated MW 434.54
• Formulation C23H30N8O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C)C(=O)C1=CC2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N1C1CCCC1
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 7 mg/mL (16.1 mM)
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rader J, et al. Clin Y Res. 2013, 19(22), 6173-6182.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting