• Product NameDAPT (GSI-IX)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.
• Target NameGamma-secretase inhibitor
• CAS No. 208255-80-5
• Calculated MW 432.46
• Formulation C23H26F2N2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
  Pathways:Neuroscience; Proteases/Proteasome; Stem Cells
  Receptor:γ secretase(Aβ)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 50 mg/mL (115.61 mM); DMSO: 86 mg/mL (198.86 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dovey HF, et al. J Neurochem. 2001, 76(1), 173-181.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting