• Product NameQNZ (EVP4593)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityQNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.
• Target NameNF-κB inhibitor; TNF inhibitor
• CAS No. 545380-34-5
• Calculated MW 356.42
• Formulation C22H20N4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:NC1=CC2=C(C=C1)N=CN=C2NCCC1=CC=C(OC2=CC=CC=C2)C=C1
  Pathways:Apoptosis; NF-κb
  Receptor:NF-κB; TNF-α
  Boling pt:
  Melting pt:
  Solubility:DMSO: 5 mg/mL (14.02 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tobe M, et al. Bioorg Med Chem, 2003, 11(3), 383-391.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting