• Product NamePHA-767491
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.
• Target NameCDK inhibitor; GSK-3 inhibitor
• CAS No. 845714-00-3
• Calculated MW 213.24
• Formulation C12H11N3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3
  Pathways:PI3K/Akt/mTOR signaling; Cell Cycle/Checkpoint; Stem Cells
  Receptor:Cdc7; CDK1; CDK2; CDK9; GSK-3β
  Boling pt:
  Melting pt:
  Solubility:DMSO:24 mg/mL (112.54 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Montagnoli A, et al. Nat Chem Biol, 2008, 4(6), 357-365.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting