• Product NameSelumetinib (AZD6244)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivitySelumetinib (AZD6244) is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. Phase 3.
• Target NameMEK inhibitor
• CAS No. 606143-52-6
• Calculated MW 457.68
• Formulation C17H15BrClFN4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C=NC2=C1C=C(C(=O)NOCCO)C(NC1=C(Cl)C=C(Br)C=C1)=C2F
  Pathways:MAPK
  Receptor:MEK1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 91 mg/mL warmed (198.82 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Huynh H, et al, Mol Y Therapy, 2007, 6 (1), 138-146

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting