• Product NamePFI-1 (PF-6405761)
• Brief DescriptionInhibitors
• Purification98.59%
• Biological ActivityPFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM in a cell-free assay.
• Target NameEpigenetic Reader Domain inhibitor
• CAS No. 1403764-72-6
• Calculated MW 347.39
• Formulation C16H17N3O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC=CC=C1S(=O)(=O)NC1=CC2=C(NC(=O)N(C)C2)C=C1
  Pathways:Chromatin/Epigenetic
  Receptor:BRD2; BRD4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 69 mg/mL (198.62 mM)
  Appearance:GrayPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fish PV, et al. J Med Chem, 2012, 55(22), 9831-9837.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting