• Product NameU0126-EtOH
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityU0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for δN3-S218E/S222D MEK than PD98059.
• Target NameCDK inhibitor; MEK inhibitor; PKC inhibitor
• CAS No. 1173097-76-1
• Calculated MW 426.6
• Formulation C18H16N6S2C2H6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
  Pathways:Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK
  Receptor:CDK2; CDK4; MEK1; MEK2; PKC
  Boling pt:
  Melting pt:
  Solubility:DMSO: 85 mg/mL warmed (199.26 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Duncia JV, et al. Bioorg Med Chem Lett. 1998, 8(20), 2839-2844.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting