• Product NamePemetrexed Disodium Hydrate
• Brief DescriptionInhibitors
• Purification99.16%
• Biological ActivityPemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
• Target NameDHFR inhibitor; DNA/RNA Synthesis inhibitor
• CAS No. 357166-30-4
• Calculated MW 516.42
• Formulation C20H21N5O65/2H2O2Na
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+]
  Pathways:DNA Damage/DNA Repair; Metabolism
  Receptor:DHFR; DHFR; GARFT; Thymidylate synthase
  Boling pt:
  Melting pt:
  Solubility:Water: 100 mg/mL warmed (193.64 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shih C, et al. Y Res. 1997, 57(6), 1116-1123.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting