• Product NameIrinotecan
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityIrinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively.
• Target NameTopoisomerase inhibitor
• CAS No. 97682-44-5
• Calculated MW 586.68
• Formulation C33H38N4O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
  Pathways:DNA Damage/DNA Repair
  Receptor:Topo I
  Boling pt:
  Melting pt:
  Solubility:DMSO: 7 mg/mL (11.93 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pavillard V, et al. Y ChemOthers Pharmacol. 2002, 49(4), 329-335.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting