• Product NameImatinib (STI571)
• Brief DescriptionInhibitors
• Purification99.94%
• Biological ActivityImatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.
• Target NameBcr-Abl inhibitor; c-Kit inhibitor; PDGFR inhibitor
• CAS No. 152459-95-5
• Calculated MW 493.6
• Formulation C29H31N7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CS(O)(=O)=O.CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC(NC3=NC=CC(=N3)C3=CN=CC=C3)=C(C)C=C2)CC1
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling
  Receptor:v-Abl; c-Kit; PDGFR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 3 mg/mL (6.07 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Buchdunger E, et al. Proc Natl Acad Sci USA. 1995, 92(7), 2558–2562.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting