• Product NameEntinostat (MS-275)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityEntinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10. Phase 3.
• Target NameHDAC inhibitor
• CAS No. 209783-80-2
• Calculated MW 376.41
• Formulation C21H20N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC1=CC=CC=C1NC(=O)C1=CC=C(CNC(=O)OCC2=CN=CC=C2)C=C1
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC1; HDAC3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 75 mg/mL (199.25 mM)
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Saito A, et al. Proc Natl Acad Sci U S A, 1999, 96(8), 4592-4597.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting