• Product NameLapatinib (GW-572016) Ditosylate
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityLapatinib Ditosylate (GW572016, GW2016) is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.
• Target NameEGFR inhibitor; Raf inhibitor; Src inhibitor
• CAS No. 388082-77-7
• Calculated MW 925.46
• Formulation C29H26ClFN4O4S2C7H8O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC=C(C=C1)S(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.CS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1
  Pathways:Angiogenesis; MAPK; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR; HER2/ErbB2; HER2/ErbB2; C-Raf-1; c-Src
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (108.05 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Rusnak DW, et al. Mol Y Ther, 2001, 1(2), 85-94.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting