• Product NamePalbociclib (PD-0332991) hydrochloride
• Brief DescriptionInhibitors
• Purification99.73%
• Biological ActivityPalbociclib (PD-0332991) HCl is a highly selective inhibitor of?CDK4/6?with?IC50?of 11 nM/16 nM respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
• Target NameCDK inhibitor
• CAS No. 827022-32-2
• Calculated MW 483.99
• Formulation C24H29N7O2HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:Cl.CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N(C2CCCC2)C1=O
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK2/CyclinA; CDK2/CyclinE2; CDK4/CyclinD1; CDK4/CyclinD3; CDK6/CyclinD2
  Boling pt:
  Melting pt:
  Solubility:Water: 30 mg/mL (61.98 mM); DMSO: 3 mg/mL warmed (6.19 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fry DW, et al. Mol Y Ther, 2004, 3(11), 1427-1438.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting