• Product NamePalbociclib (PD0332991) Isethionate
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPalbociclib (PD0332991) Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
• Target NameCDK inhibitor
• CAS No. 827022-33-3
• Calculated MW 573.66
• Formulation C24H29N7O2C2H6O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OCCS(O)(=O)=O.CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N(C2CCCC2)C1=O
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK2/CyclinA; CDK2/CyclinE2; CDK4/CyclinD1; CDK4/CyclinD3; CDK6/CyclinD2
  Boling pt:
  Melting pt:
  Solubility:Water: 50 mg/mL warmed (87.15 mM)
  Appearance:YellowPowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fry DW, et al. Mol Y Ther, 2004, 3(11), 1427-1438.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting