• Product NameCobicistat (GS-9350)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.
• Target NameP450 inhibitor
• CAS No. 1004316-88-4
• Calculated MW 776.02
• Formulation C40H53N7O5S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:CC(C)C1=NC(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC2=CC=CC=C2)NC(=O)OCC2=CN=CS2)CC2=CC=CC=C2)=CS1 |r,c:32,34,44,51,53,55,t:3,30,42,49|
  Pathways:Metabolism
  Receptor:CYP3A
  Boling pt:
  Melting pt:
  Solubility:DMSO:100 mg/mL (128.86 mM)Ethanol:100 mg/mL (128.86 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Xu L, et al. ACS Med. Chem. Lett, 2010, 1(5), 209-213.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting