• Product NameH 89 2HCl
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityH 89 2HCl is a potent PKA inhibitor with Ki of 48 nM, 10-fold selective for PKA than PKG, greater than 500-fold selectivity than PKC, MLCK, calmodulin kinase II and casein kinase I/II.
• Target NamePKA inhibitor; S6 Kinase inhibitor
• CAS No. 130964-39-5
• Calculated MW 519.28
• Formulation C20H20BrN3O2S.2HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNC/C=C/C3=CC=C(C=C3)Br.Cl.Cl
  Pathways:GPCR/G Protein; PI3K/Akt/mTOR signaling
  Receptor:PKA; S6K1
  Boling pt:
  Melting pt:
  Solubility:DMSO:104 mg/mL (200.27 mM)Ethanol:<1 mg/mL (<1 mM)Water6 mg/mL (11.55 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chijiwa T, et al. J Biol Chem., 1990, 265(9), 5267-5272.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting