• Product NamePF-04691502
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPF-04691502 is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. Phase 2.
• Target NameAkt inhibitor; PI3K inhibitor
• CAS No. 1013101-36-4
• Calculated MW 425.48
• Formulation C22H27N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC=C(C=N1)C1=CC2=C(C)N=C(N)N=C2N([C@H]2CC[C@@H](CC2)OCCO)C1=O |r,c:4,6,11,17,t:2,9,14|
  Pathways:Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
  Receptor:P-Akt (S473); PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO:14 mg/mL (32.9 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yuan J, Mol Cancer Ther, 2011, 10(11), 2189-2199

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting