• Product NameIpatasertib (GDC-0068)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityIpatasertib (GDC-0068) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA. Phase 2.
• Target NameAkt inhibitor
• CAS No. 1001264-89-6
• Calculated MW 458
• Formulation C24H32ClN5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)NC[C@@H](C(=O)N1CCN(CC1)C1=C2[C@H](C)C[C@@H](O)C2=NC=N1)C1=CC=C(Cl)C=C1 |r,c:15,23,25,33,t:28,30|
  Pathways:Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
  Receptor:Akt1; Akt2; Akt3
  Boling pt:
  Melting pt:
  Solubility:DMSO:92 mg/mL (200.87 mM)Ethanol:92 mg/mL (200.87 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lin K. Cancer Res, 2011, 71(8 Supplement), abstract DDT02-01.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting