• Product NameAZ191
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.
• Target NameDYRK inhibitor
• CAS No. 1594092-37-1
• Calculated MW 429.52
• Formulation C24H27N7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=C(NC2=NC=CC(=N2)C2=CN(C)C3=C2C=CN=C3)C=CC(=C1)N1CCN(C)CC1
  Pathways:Cell Cycle/Checkpoint
  Receptor:DYRK1A; DYRK1B; DYRK2
  Boling pt:
  Melting pt:
  Solubility:DMSO:86 mg/mL (200.22 mM)Ethanol:1 mg/mL (2.32 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ashford AL, et al. Biochem J. 2014, 457(1), 43-56.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting