• Product NamePP2
• Brief DescriptionInhibitors
• Purification95.65%
• Biological ActivityPP2, a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA.
• Target NameEGFR inhibitor; JAK inhibitor; Src inhibitor; Tyrosine Kinases inhibitor
• CAS No. 172889-27-9
• Calculated MW 301.77
• Formulation C15H16ClN5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)(C)N1N=C(C2=C1N=CN=C2N)C1=CC=C(Cl)C=C1
  Pathways:Angiogenesis; Proteases/Proteasome; Chromatin/Epigenetic; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Stem Cells
  Receptor:EGFR; JAK2; Fyn; Lck; ZAP70
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (6.62 mM); DMSO: 60 mg/mL (198.82 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hanke JH, et al. J Biol Chem, 1996, 271(2), 695-701.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting