• Product NameR428 (BGB324)
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityR428 (BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).
• Target NameTAM Receptor inhibitor
• CAS No. 1037624-75-1
• Calculated MW 506.64
• Formulation C30H34N8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1CCN(C1)[C@H]2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:AXL
  Boling pt:
  Melting pt:
  Solubility:DMSO:24 mg/mL warmed (47.37 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Holland SJ, et al. Cancer Res, 2010, 70(4), 1544-1554.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting