• Product NameTipifarnib
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityTipifarnib (R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.
• Target NameTransferase inhibitor
• CAS No. 192185-72-1
• Calculated MW 489.4
• Formulation C27H22Cl2N4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
  Pathways:Metabolism
  Receptor:Farnesyl transferase (FTase)
  Boling pt:
  Melting pt:
  Solubility:DMSO:14 mg/mL (28.6 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Margolin KA, et al. Clin Y Res. 2012, 18(4), 1129-1137.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting