• Product NameFosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium
• Brief DescriptionInhibitors
• Purification99.83%
• Biological ActivityFosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Phase 3.
• Target NameMicrotubule Associated inhibitor
• CAS No. 168555-66-6
• Calculated MW 440.29
• Formulation C18H19O8P.2Na
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]
  Pathways:Cytoskeletal Signaling
  Receptor:Tubulin
  Boling pt:
  Melting pt:
  Solubility:DMSO:<1 mg/mL (<1 mM)Ethanol:<1 mg/mL (<1 mM)Water:28 mg/mL (63.59 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Woods JA, et al. Br J Cancer 1995, 71(4), 705-711.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting