• Product NameDMXAA (Vadimezan)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM, respectively. Phase 3.
• Target NameVDA inhibitor
• CAS No. 117570-53-3
• Calculated MW 282.29
• Formulation C17H14O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cardiovascular System
  SMILES:CC1=C(C)C2=C(C=C1)C(=O)C1=C(O2)C(CC(O)=O)=CC=C1 |c:1,4,6,11,19,21|
  Pathways:Angiogenesis
  Receptor:DT-diaphorase
  Boling pt:
  Melting pt:
  Solubility:DMSO:7 mg/mL (24.79 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Phillips RM. Biochem Pharmacol. 1999, 58(2), 303-310.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting