• Product NameRO4929097
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityRO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.
• Target NameBeta Amyloid inhibitor; Gamma-secretase inhibitor
• CAS No. 847925-91-1
• Calculated MW 469.4
• Formulation C22H20F5N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)(C(=O)NCC(F)(F)C(F)(F)F)C(=O)N[C@H]1C2=C(C=CC=C2)C2=C(NC1=O)C=CC=C2 |r,c:20,22,25,31,33,t:18|
  Pathways:Neuroscience; Proteases/Proteasome; Stem Cells
  Receptor:Aβ40; γ secretase; γ secretase(ICN)
  Boling pt:
  Melting pt:
  Solubility:DMSO:94 mg/mL (200.25 mM)Ethanol:16 mg/mL (34.08 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Luistro L, et al. Cancer Res. 2009, 69(19), 7672-7680.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting