• Product NameNU7441 (KU-57788)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityNU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM.
• Target NameATM/ATR inhibitor; DNA-PK inhibitor; mTOR inhibitor; PI3K inhibitor
• CAS No. 503468-95-9
• Calculated MW 413.49
• Formulation C25H19NO3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:O=C1C=C(OC2=C1C=CC=C2C1=CC=CC2=C1SC1=CC=CC=C21)N1CCOCC1
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:ATM; ATR; DNA-PK; mTOR; PI3K
  Boling pt:
  Melting pt:
  Solubility:DMSO: 3 mg/mL (7.25 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Leahy JJ, et al. Bioorg Med Chem Lett, 2004, 14(24), 6083-6087.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting