• Product NameBIRB 796 (Doramapimod)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.
• Target Namep38 MAPK inhibitor
• CAS No. 285983-48-4
• Calculated MW 527.66
• Formulation C31H37N5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC=C(C=C1)N1N=C(C=C1NC(=O)NC1=CC=C(OCCN2CCOCC2)C2=C1C=CC=C2)C(C)(C)C |c:3,5,9,11,32,35,37,t:1,18,20|
  Pathways:MAPK
  Receptor:p38α; p38α
  Boling pt:
  Melting pt:
  Solubility:DMSO:106 mg/mL (200.88 mM)Ethanol:106 mg/mL (200.88 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pargellis C, et al. Nat Struct Biol, 2002, 9(4), 268-272.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting