• Product NameSotrastaurin
• Brief DescriptionInhibitors
• Purification99.41%
• Biological ActivitySotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM; inactive to PKCζ. Phase 2.
• Target NamePKC inhibitor
• CAS No. 425637-18-9
• Calculated MW 438.48
• Formulation C25H22N6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CN1CCN(CC1)C1=NC2=CC=CC=C2C(=N1)C1=C(C(=O)NC1=O)C1=CNC2=CC=CC=C12
  Pathways:Cytoskeletal Signaling
  Receptor:PKCα; PKCβ1; PKCδ; PKCη; PKCθ
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 2 mg/mL (4.56 mM); DMSO: 87 mg/mL (198.41 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Evenou JP, et al. J Pharmacol Exp Ther, 2009, 330(3), 792-801.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting