• Product NameEnzastaurin (LY317615)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityEnzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3.
• Target NamePKC inhibitor
• CAS No. 170364-57-5
• Calculated MW 515.61
• Formulation C32H29N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CN1C=C(C2=CC=CC=C12)C1=C(C(=O)NC1=O)C1=CN(C2CCN(CC3=NC=CC=C3)CC2)C2=CC=CC=C12 |c:2,6,30,32,40,t:4,8,12,20,28,38,42|
  Pathways:Cytoskeletal Signaling
  Receptor:PKCα; PKCβ; PKCγ; PKCε
  Boling pt:
  Melting pt:
  Solubility:DMSO:30 mg/mL (58.18 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Graff JR, et al. Cancer Res, 2005, 65(16), 7462-7469.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting