• Product NameTW-37
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityTW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.
• Target NameBCL inhibitor; Bcr-Abl inhibitor
• CAS No. 877877-35-5
• Calculated MW 573.7
• Formulation C33H35NO6S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)C1=CC=CC=C1CC1=CC(C(=O)NC2=CC=C(C=C2)S(=O)(=O)C2=C(C=CC=C2)C(C)(C)C)=C(O)C(O)=C1O |c:5,7,19,21,29,31,41,t:3,11,17,27,37|
  Pathways:Angiogenesis; Apoptosis; Cytoskeletal Signaling
  Receptor:Mcl-1; Bcl-2; Bcl-xL
  Boling pt:
  Melting pt:
  Solubility:DMSO:115 mg/mL (200.45 mM)Ethanol:4 mg/mL (6.97 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mohammad RM, et al. Clin Cancer Res, 2007, 13(7), 2226-2235.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting