• Product NameDovitinib (TKI-258, CHIR-258)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2. Phase 4.
• Target Namec-Kit inhibitor; FGFR inhibitor; FLT inhibitor; VEGFR inhibitor
• CAS No. 405169-16-6
• Calculated MW 392.43
• Formulation C21H21FN6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C/4\C(=C5C(=NC4=O)C=CC=C5F)N)/N3
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:c-Kit; FGFR1; FGFR3; FLT3; VEGFR3/FLT4
  Boling pt:
  Melting pt:
  Solubility:DMSO:30 mg/mL (76.44 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Trudel S, et al. Blood. 2005, 105(7), 2941-2948.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting