• Product NameWZ4003
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityWZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively, without significant inhibition on 139 other kinases.
• Target NameAMPK inhibitor
• CAS No. 1214265-58-3
• Calculated MW 496.99
• Formulation C25H29ClN6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCC(=O)NC1=CC=CC(OC2=NC(NC3=C(OC)C=C(C=C3)N3CCN(C)CC3)=NC=C2Cl)=C1 |c:7,15,19,21,31,33,36,t:5,11|
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:NUAK1; NUAK2
  Boling pt:
  Melting pt:
  Solubility:DMSO:7 mg/mL (14.08 mM)Ethanol:<1 mg/mL (<1 mM)Water<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Banerjee S, et al. Biochem J. 2014, 457(1), 215-225.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting