• Product NameNVP-BSK805 2HCl
• Brief DescriptionInhibitors
• Purification98.75%
• Biological ActivityNVP-BSK805 2HCl is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM,>20-fold selectivity towards JAK1, JAK3 and TYK2.
• Target NameJAK inhibitor; Tyrosine Kinases inhibitor
• CAS No. 1092499-93-8
• Calculated MW 563.47
• Formulation C27H28F2N6O.2HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl
  Pathways:Angiogenesis; Proteases/Proteasome; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:JAK1; JAK2; JAK3; Tyk2
  Boling pt:
  Melting pt:
  Solubility:DMSO:113 mg/mL (200.54 mM)Ethanol:15 mg/mL (26.62 mM)Water3 mg/mL (5.32 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Baffert F, et al. Mol Cancer Ther, 2010, 9(7), 1945-1955.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting