• Product NameGDC-0152
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.
• Target NameIAP antagonist
• CAS No. 873652-48-3
• Calculated MW 498.64
• Formulation C25H34N6O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NC1=C(N=NS1)C1=CC=CC=C1 |r,c:28,34,36,t:26,32|
  Pathways:Apoptosis
  Receptor:cIAP1-BIR3; cIAP2-BIR3; MLXBIR3SG; XIAP-BIR2; XIAP-BIR3
  Boling pt:
  Melting pt:
  Solubility:DMSO:99 mg/mL (198.54 mM)Ethanol:99 mg/mL (198.54 mM)Water:3 mg/mL (6.01 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Flygare JA, et al. J Med Chem, 2012, 55(9), 4101-4113.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting