• Product NameLonafarnib
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Phase 3.
• Target NameRaf inhibitor; Ras inhibitor
• CAS No. 193275-84-2
• Calculated MW 638.82
• Formulation C27H31Br2ClN4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism system
  SMILES:NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2C3=C(CCC4=C2C(Br)=CC(Cl)=C4)C=C(Br)C=N3)CC1 |r,c:18,22,26,29,35,t:32|
  Pathways:MAPK
  Receptor:K-ras-4B; H-ras; N-ras
  Boling pt:
  Melting pt:
  Solubility:DMSO:127 mg/mL (198.8 mM)Ethanol:127 mg/mL (198.8 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liu M, et al. Cancer Res, 1998, 58(21), 4947-4956.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting