• Product NameSNX-2112 (PF-04928473)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivitySNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.
• Target NameHSP inhibitor
• CAS No. 908112-43-6
• Calculated MW 464.48
• Formulation C23H27F3N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1(C)CC2=C(C(=NN2C2=CC(NC3CCC(O)CC3)=C(C=C2)C(N)=O)C(F)(F)F)C(=O)C1
  Pathways:Cytoskeletal Signaling; Metabolism
  Receptor:HSP90α; HSP90β
  Boling pt:
  Melting pt:
  Solubility:DMSO:93 mg/mL (200.22 mM)Ethanol:1 mg/mL (2.15 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chandarlapaty S, et al, Clin Y Res, 2008, 14(1), 240-248.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting