• Product NameAZ 960
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3.
• Target NameJAK inhibitor
• CAS No. 905586-69-8
• Calculated MW 354.36
• Formulation C18H16F2N6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=CC(=NN1)NC2=C(C=C(C(=N2)N[C@@H](C)C3=CC=C(C=C3)F)C#N)F
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:JAK2; JAK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 3 mg/mL (8.46 mM); DMSO: 71 mg/mL (200.36 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gozgit JM, et al. J Biol Chem. 2008, 283(47), 32334-32343.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting