• Product NameBafetinib (INNO-406)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityBafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. Phase 2.
• Target NameBcr-Abl inhibitor; Src inhibitor
• CAS No. 859212-16-1
• Calculated MW 576.62
• Formulation C30H31F3N8O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C)[C@H]1CCN(CC2=CC=C(C=C2C(F)(F)F)C(=O)NC2=CC=C(C)C(NC3=NC=C(C=N3)C3=CN=CN=C3)=C2)C1 |r,c:10,12,31,33,38,40,42,t:8,22,24,29,36|
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:Abl; Lyn
  Boling pt:
  Melting pt:
  Solubility:DMSO:100 mg/mL (173.42 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kimura S, et al. Blood. 2005, 106(12), 3948-3954.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting