• Product NameGo 6983
• Brief DescriptionInhibitors
• Purification99.04%
• Biological ActivityGo 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively; less potent to PKCζ and inactive to PKCμ.
• Target NamePKC inhibitor
• CAS No. 133053-19-7
• Calculated MW 442.51
• Formulation C26H26N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
  Pathways:Cytoskeletal Signaling
  Receptor:PKCα; PKCβ; PKCγ; PKCδ; PKCζ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 59 mg/mL (133.33 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gschwendt M, et al. FEBS Lett, 1996, 392(2), 77-80.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting