• Product NameMLN8054
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityMLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM. It is more than 40-fold selective for Aurora A than Aurora B. Phase 1.
• Target NameAurora Kinase inhibitor; Casein Kinase inhibitor; PKA inhibitor; Src inhibitor
• CAS No. 869363-13-3
• Calculated MW 476.86
• Formulation C25H15ClF2N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCOC(=O)C1CC2=C(NC(=O)C1)C=C(OC)C=C2
  Pathways:Cell Cycle/Checkpoint; Metabolism; Angiogenesis; GPCR/G Protein; Chromatin/Epigenetic; Stem Cells
  Receptor:Aurora A; Aurora B; CK2; PKA; Lck
  Boling pt:
  Melting pt:
  Solubility:DMSO:95 mg/mL (199.21 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Manfredi MG, et al. Proc Natl Acad Sci U S A, 2007, 104(10), 4106-4111.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting