• Product NameGDC-0879
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGDC-0879 is a novel, potent, and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well; no inhibition known to other protein kinases.
• Target NameRaf inhibitor
• CAS No. 905281-76-7
• Calculated MW 334.37
• Formulation C19H18N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1C/C(=N\O)/C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO
  Pathways:MAPK
  Receptor:B-Raf
  Boling pt:
  Melting pt:
  Solubility:DMSO:66 mg/mL warmed (197.38 mM)Ethanol:5 mg/mL (14.95 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wong H, et al. J Pharmacol Exp Ther. 2009, 329(1), 360-367.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting