• Product NameBAY 80-6946 (Copanlisib)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityBAY 80-6946 (Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM. Phase 2.
• Target NamePI3K inhibitor
• CAS No. 1032568-63-0
• Calculated MW 480.52
• Formulation C23H28N8O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
  Boling pt:
  Melting pt:
  Solubility:DMSO:0.002 mg/mL (0.0 mM)Ethanol:0.01 mg/mL (0.02 mM)Water0.002 mg/mL (0.0 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Patnaik A, et al. J Clin Oncol, 29, 2011, (suppl, abstr 3035)

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting