• Product NameBIX02188
• Brief DescriptionInhibitors
• Purification99.01%
• Biological ActivityBIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
• Target NameERK inhibitor; MEK inhibitor; TGF-beta/Smad inhibitor
• CAS No. 1094614-84-2
• Calculated MW 412.48
• Formulation C25H24N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N)NC2=O)/C4=CC=CC=C4
  Pathways:MAPK; Stem Cells
  Receptor:ERK5; MEK1; MEK2; MEK5; TGFβR1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mM
  Appearance:Yellow Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tatake RJ, et al. Biochem Biophys Res Commun, 2008, 377(1), 120-125.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting