• Product NamePCI-34051
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10.
• Target NameHDAC inhibitor
• CAS No. 950762-95-5
• Calculated MW 296.32
• Formulation C17H16N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:COC1=CC=C(CN2C=CC3=C2C=C(C=C3)C(=O)NO)C=C1 |c:8,10,13,15,22,t:2,4|
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC1; HDAC10; HDAC2; HDAC6; HDAC8
  Boling pt:
  Melting pt:
  Solubility:DMSO:59 mg/mL (199.1 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Balasubramanian S, et al. Leukemia. 2008, 22(5), 1026-1034.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting