• Product NameMLN4924
• Brief DescriptionInhibitors
• Purification95.00%
• Biological ActivityMLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM).
• Target NameE1 Activating inhibitor
• CAS No. 905579-51-3
• Calculated MW 669.8
• Formulation C35H49F2N7O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C1CC2=CC=CC=C2[C@H]1NC3=NC=NC4=C3C=CN4[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N
  Pathways:Ubiquitination
  Receptor:NAE
  Boling pt:
  Melting pt:
  Solubility:DMSO: > 50 mg/mL
  Appearance:WhitePowder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Soucy TA, et al. Nature. 2009 Apr 9;458(7239):732-6.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting