• Product NameRepSox
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityRepSox is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively.
• Target NameALK inhibitor; TGF-beta/Smad inhibitor
• CAS No. 446859-33-2
• Calculated MW 287.32
• Formulation C17H13N5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=CC=CC(=N1)C1=C(C=NN1)C1=NC2=C(C=C1)N=CC=C2
  Pathways:Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
  Receptor:ALK5; TGFβR1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 57 mg/mL (198.38 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gellibert F, et al. J Med Chem, 2004, 47(18), 4494-4506.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting